By Stephen Beech via SWNS
Posture affects how the stomach absorbs drugs taken orally, suggests a new study.
Researchers used a state-of-the-art "StomachSim" - based on the realistic anatomy of the human stomach – to analyze and quantify how effective swallowed medicines are.
Scientists say that swallowing tablets is the most complex way for the human body to absorb an active pharmaceutical ingredient because the bioavailability of the drug in the gastrointestinal tract depends on the medication's ingredients and the stomach's dynamic physiological environment.
American scientists used a biomimetic in-silico simulator based on the realistic anatomy and morphology of the stomach – dubbed a "StomachSim" – for the study.
They said the modeling is believed to be the first of its kind to couple gastric biomechanics with pill movement and drug dissolution to quantify an active pharmaceutical ingredient passing through the pylorus into the duodenum.
It enabled the researchers to calculate and compare the emptying rate and the release of a dissolved active pharmaceutical ingredient into the duodenum for a variety of physiological situations.
Study co-author Professor Rajat Mittal, of Johns Hopkins University, said: "Oral administration is surprisingly complex despite being the most common choice for drug administration.
"When the pill reaches the stomach, the motion of the stomach walls and the flow of contents inside determine the rate at which it dissolves. The properties of the pill and the stomach contents also play a major role.
"However, current experimental or clinical procedures for assessing the dissolution of oral drugs are limited in their ability to study this, which makes it a challenge to understand how the dissolution is affected in different stomach disorders, such as gastroparesis, which slows down the emptying of the stomach."
He said the stomach's contents and gastric fluid dynamics are among factors that play a role in a drug's bioavailability, and stomach contractions can induce pressure and generate complex pill trajectories.
Mittal said: "This results in varying rates of pill dissolution and non-uniform emptying of the drug into the duodenum and, sometimes, gastric dumping in the case of modified-release dosage.
"Together, these issues pose several challenges for the design of drug delivery."
Mittal added: "In this work, we demonstrate a novel computer simulation platform that offers the potential for overcoming these limitations.
"Our models can generate biorelevant data on drug dissolution that can provide useful and unique insights into the complex physiological processes behind the oral administration of pills."
The findings were published in the journal Physics of Fluids.
Stories and infographics by ‘Talker Research’ are available to download & ready to use. Stories and videos by ‘Talker News’ are managed by SWNS. To license content for editorial or commercial use and to see the full scope of SWNS content, please email email@example.com or submit an inquiry via our contact form.
NASA builds interactive map that lets people ‘hike’ Mars
The vast map encompasses the areas surrounding the landing site of NASA’s Mars 2020 Perseverance rover.
This fencer is still winning at 89
"I was 63 when I started, at a time of life when a lot of people put their feet up,...
Nearly 80% say the best part of their day is coming home to their pet
This story version has been formatted as an on-air script for broadcast outlets. See the original research story here. NEW...
Burmese pythons wreaking havoc in Florida
Researchers routinely find deer hooves and the remains of other big animals in their stomachs.
200-year-old tribal paddle discovered 10,000 miles from home
Experts believe whoever acquired the paddle 192 years ago may have been inspired by Captain Cook.
- Animals4 days ago
Massive 12-foot alligator captured in residential neighborhood
- Animals4 days ago
Great white shark fitted with GPS tracker draws self-portrait
- Food & Drink4 days ago
340-pound pumpkin so huge it needs a forklift to be weighed
- Health4 days ago
Virus similar to COVID-19 identified in Russian bat
- Travel4 days ago
World’s first real sheep-counting sleep vacation unveiled
- News3 days ago
Abortion providers share the deadly dangers of the job
- Art4 days ago
Cyclist creates GPS drawings of animals
- Nature15 hours ago
World’s largest collection of rare orchid discovered growing along military base