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Food & Drink

Study says sugar substitutes could cause diabetes

Manufacturers have long claimed they have no effect on the human body.

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By Mark Waghorn via SWNS

Artificial sweeteners could give you diabetes, according to new research.

They affect gut bacteria - potentially altering blood glucose levels, scientists say.

Many switch to them to get a sweet-tooth rush - without the calories.

Sugar substitutes are also in thousands of diet products such as fizzy drinks, desserts, ready meals and cakes.

They include saccharin and aspartame - even found in chewing gum and toothpaste.

Manufacturers have long claimed they have no effect on the human body.

But researchers have now discovered they are far from inert.

In fact, some can alter consumers' microbiomes in a way that changes blood sugar.

Senior author Professor Eran Elinav, of the German National Cancer Centre, said: "In subjects consuming the non-nutritive sweeteners, we could identify very distinct changes in the composition and function of gut microbes, and the molecules they secret into the peripheral blood.

"This seemed to suggest gut microbes in the human body are rather responsive to each of these sweeteners.

"When we looked at consumers of non-nutritive sweeteners as groups, we found two of the non-nutritive sweeteners, saccharin and sucralose, significantly impacted glucose tolerance in healthy adults.

"Interestingly, changes in the microbes were highly correlated with the alterations noted in people's glycaemic responses."

In 2014, his team identified the same phenomenon in mice. They wanted to see if it also happened in humans.

Elinav and colleagues screened more than 1,300 people, identifying 120 who strictly avoided artificial sweeteners in their day-to-day lives.

The latter was broken into six groups - two controls and four who ingested well below the daily allowance of either aspartame, saccharin, stevia or sucralose recommended by the US Food and Drug Administration (FDA).

Microbial samples from the subjects were injected into germ-free mice raised in completely sterile conditions with no gut bacteria of their own.

food, junk-food, diet and unhealthy eating concept - close up of white sugar pyramid on wooden table over red circle-backslash no sign
(Ground Picture via Shutterstock)

Elinav said: "The results were quite striking. In all of the non-nutritive sweetener groups, but in none of the controls, when we transferred into these sterile mice the microbiome of the top responder individuals collected at a time point in which they were consuming the respective non-nutritive sweeteners, the recipient mice developed glycemic alterations that very significantly mirrored those of the donor individuals.

"In contrast, the bottom responders’ microbiomes were mostly unable to elicit such glycaemic responses.

"These results suggest that the microbiome changes in response to human consumption of non-nutritive sweetener may, at times, induce glycaemic changes in consumers in a highly personalized manner."

He expects the effects of the sweeteners will vary from person to person because of the incredibly unique composition of our microbiome.

Elinav added: "We need to raise awareness of the fact that non-nutritive sweeteners are not inert to the human body as we originally believed.

"With that said, the clinical health implications of the changes they may elicit in humans remain unknown and merit future long-term studies.

“In the meantime, we need to continue searching for solutions to our sweet tooth craving, while avoiding sugar, which is clearly most harmful to our metabolic health. In my personal view, drinking only water seems to be the best solution."

The findings, published in the journal Cell, follow previous research suggesting sweeteners have adverse effects on metabolism and appetite control.

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