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Robotic pill from MIT could replace injections for diabetics

It's about the size of a blueberry and made from biodegradable polymer with stainless steel components.

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The robotic pill, being developed at MIT, next to a penny for scale. (MIT via SWNS)

By Mark Waghorn via SWNS

A robotic pill that delivers insulin directly to the gut could replace multiple painful injections for people with diabetes.

It can also deliver antibiotics, offering hope of battling superbugs with oral medications.

For patients and physicians, taking treatments by mouth is most desirable. Swallowing is safer, more convenient and less invasive.

But the drugs often cannot withstand stomach acids before unleashing their payloads for the intended effects. The degradation makes them less effective.

The new capsule, called RoboCap, could revolutionize therapy. In a swine model, it increased permeability for insulin more than tenfold.

medicine, diabetes, health care and people concept - close up of woman hands holding syringes
(Ground Picture via Shutterstock)

Similar results were seen for vancomycin - an antibiotic that is usually delivered intravenously.

Lead author Dr. Giovanni Traverso, of the Massachusetts Institute of Technology (MIT), said: "Peptides and proteins are important drugs.

"But the degradative environment of the gastrointestinal tract and poor absorption has limited the ability to deliver these drugs orally."

Pigs have anatomical, physiological and biochemical similarities to humans - making them ideal for research.

Dr. Traverso added: "RoboCap’s mucus-clearing and churning movements are designed to overcome these barriers and help deliver drugs to where they are needed."

medicine, diabetes, glycemia, health care and people concept - close up of woman with syringe making insulin injection to himself at home
(Ground Picture via Shutterstock)

About the size of a blueberry, the inexpensive device is made from a biodegradable polymer and stainless steel components.

It makes it through the harsh environment of the stomach, resisting attacks from enzymes and penetrating the small intestine's mucus barrier and other obstacles.

Dr. Traverso said: "When ingested, RoboCap's gelatinous coating is dissolved in the stomach.

"The environment of the small intestine activates RoboCap, which vibrates and rotates to clear mucus, enhance mixing and deposit the drug payload in the small intestine where the drug is likely to be absorbed.

"Our motivation is to make it easier for patients to take medication, particularly medications that require an injection. The classic one is insulin - but there are many others."

Many diabetics require several doses of insulin to manage their condition daily. The standard delivery method is via injections with small needles many times a day.

It can be especially uncomfortable, and unwieldy and is harder than just taking a pill.

The Centers for Disease Control and Prevention reports that 37 million Americans - or more than one-in-ten - suffer from diabetes.

It is the eighth leading cause of death in America, responsible for just over 100,00 fatalities each year.

Insulin is naturally produced in the pancreas, then travels to the liver where it helps process blood sugar.

A person suffering from type 1 diabetes does not produce enough insulin to manage blood sugar - if at all. All patients require some sort of dosage to manage the condition.

Those with type 2 diabetes, the form linked to obesity, may also need insulin medication to boost levels of the hormone and manage their blood sugar.

The standard injection of insulin is 100 international units (iu) per shot. A vast majority is lost during oral delivery.

Previous attempts to develop an insulin pill have had to carry around 500iu to properly function.

RoboCap is described in the journal Science Robotics.

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