Ashkenazi Jewish community more diverse 600 years ago than now

By Stephen Beech via SWNS

The Ashkenazi Jewish community was more diverse 600 years ago than it is today, according to new research.

DNA extracted from teeth taken from a Jewish cemetery gave unprecedented insight into the lives of a once-thriving medieval Ashkenazi community in Erfurt, Germany.

The findings, published in the scientific journal Cell, show that the Erfurt Jewish community was more genetically diverse than modern-day Ashkenazi Jews.

Geneticist and co-corresponding author Dr. Shai Carmi said: “Today, if you compare Ashkenazi Jews from the United States and Israel, they’re very similar genetically, almost like the same population regardless of where they live.”

But unlike today’s genetic uniformity, it turns out that the community was more diverse 600 years ago.

Digging into the ancient DNA of 33 Ashkenazi Jews from medieval Erfurt, the researchers discovered that the community can be categorized into what seems like two groups.

One relates more to individuals from Middle Eastern populations and the other to European populations, possibly including migrants to Erfurt from the east.

The findings suggest that there were at least two genetically distinct groups in medieval Erfurt. However, that variation in ancestral origins no longer exists in modern Ashkenazi Jews.

Dr. Carmi, an Associate Professor at the Hebrew University of Jerusalem, said: “Our goal was to fill the gaps in our understanding of Ashkenazi Jewish early history through ancient DNA data."

He explained that while ancient DNA data are a powerful tool to infer historical demographics, ancient Jewish DNA data are hard to come by, as Jewish law prohibits the disturbance of the dead in most circumstances.

However, with the approval of the local Jewish community in Germany, the research team collected detached teeth from remains found in a 14th Century Jewish cemetery in Erfurt that underwent a rescue excavation.

The researchers also discovered that the "founder" event - which makes all Ashkenazi Jews today descendants of a small population - happened before the 14th Century.

For example, teasing through mitochondrial DNA, the genetic materials we inherit from our mothers, they discovered that a third of the sampled Erfurt individuals share one specific sequence.

The findings indicate that the early Ashkenazi Jewish population was so small that a third of Erfurt individuals descended from a single woman through their maternal lines.

At least eight of the Erfurt individuals also carried disease-causing genetic mutations common in modern-day Ashkenazi Jews but rare in other populations - a hallmark of the Ashkenazi Jewish founder event.

Geneticist and co-corresponding author Professor David Reich, of Harvard University, said: “Jews in Europe were a religious minority that was socially segregated, and they experienced periodic persecution.

"Although antisemitic violence virtually wiped out Erfurt’s Jewish community in 1349, Jews returned five years later and grew into one of the largest in Germany.

“Our work gives us direct insight into the structure of this community.”

The researchers believe their study helps to establish an "ethical basis" for studies of ancient Jewish DNA.

But they say many questions remain unanswered, such as how medieval Ashkenazi Jewish communities became genetically differentiated, how early Ashkenazi Jews related to Sephardi Jews, and how modern Jews relate to ones from ancient Judea.

Prof Reich added: “This work also provides a template for how a co-analysis of modern and ancient DNA data can shed light on the past.

“Studies like this hold great promise not only for understanding Jewish history but also that of any population.”